FLT3/CHK1-IN-1

FLT3/CHK1-IN-1

• CAS Number: 2991054-23-8
• UNSPSC Description: FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC50 value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-chk1-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: N[C@H]1CC[C@@H](NC2=NC(NC3=CC4=C(C=C3)CN(C(CC(O)(C)C)=O)CC4)=NC=C2C(F)(F)F)CC1
• Molecular Weight: 506.56
• References & Citations: [1]Li X, et al. Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities. J Med Chem. 2023 Sep 14;66(17):11792-11814.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported