FLT3/CHK1-IN-2

• UNSPSC Description:

  FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of FLT3 and CHK1, with IC50s of 25.63, 16.39, 22.80 nM for CHK1, FLT3-WT, and FLT-D835Y respectively. FLT3/CHK1-IN-2 has favorable oral PK properties and kinase selectivity. FLT3/CHK1-IN-2 can be used for research of acute myeloid leukemia (AML)[1].

• Target Antigen:

  Checkpoint Kinase (Chk); FLT3

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-chk1-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCCNC1=NC(NC2=CC(CCN(S(=O)(C)=O)C3)=C3C=C2)=NC=C1C(F)(F)F

• Molecular Weight:

  444.47

• References & Citations:

  [1]Deng M, et al. Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1. RSC Med Chem. 2023 Dec 7;15(2):539-552.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported