PRMT5-IN-1 (hydrochloride)

PRMT5-IN-1 (hydrochloride)

• UNSPSC Description: PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/prmt5-in-1-hydrochloride.html
• Purity: 99.50
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O[C@@H]1[C@@H]([C@@H](C2=CC=C(Cl)C=C2)O)O[C@@H](N3C=CC4=C3N=CN5C4=NCC5O)[C@@H]1O.[H]Cl
• Molecular Weight: 455.29
• References & Citations: [1]Lin H, et, al. Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. ACS Med Chem Lett. 2019 May 22;10(7):1033-1038.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported