TYK2-IN-12
CAT:
804-HY-150720-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TYK2-IN-12
- CAS Number: 2244061-66-1
- UNSPSC Description: TYK2-IN-12 (compound 30) is an orally active, potent and selective TYK2 (tyrosine kinase 2) inhibitor, with a Ki of 0.51 nM. TYK2-IN-12 inhibits IL-12 induced IFNγ, with IC50 values of 2.7 and 7.0 μM in human and mouse whole blood, respectively. TYK2-IN-12 can be used for psoriasis research[1].
- Target Antigen: IFNAR; JAK
- Type: Reference compound
- Related Pathways: Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/tyk2-in-12.html
- Solubility: DMSO : 7.14 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: FC1=CC=CC(F)=C1C2=NC(CN3)=C(C(NC4=CC=C(C(N5CCCC5)=O)C=C4)=C2)C3=O
- Molecular Weight: 434.44
- References & Citations: [1]Leit S, et al. Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg Med Chem Lett. 2022 Jul 13;73:128891.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported