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2-Hydroxyquinoline

CAT: 0804-HY-W005598-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W005598-01Size:1 g
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Description
2-Hydroxyquinoline is an inhibitor of α-glucosidase and α-amylase with IC50 values of 64.4 µg/mL and 130.5 µg/mL, respectively. 2-Hydroxyquinoline can be used in the study of diabetes[1].
CAS Number
59-31-4
UNSPSC
12352200
Hazard Statement
H302, H315, H318, H335
Target
Amylases; Glycosidase
Type
Biochemical Assay Reagents
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-hydroxyquinoline.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC=CC=C2N1
Molecular Formula
C9H7NO
Molecular Weight
145.16
Precautions
H302, H315, H318, H335
References & Citations
[1]Hwa-Won Lee, et al. 2-Hydroxyquinoline and Its Structural Analogs Show Antidiabetic Effects against α-Amylase and α-Glucosidase. Journal of Applied Biological Chemistry (2015) 58 (1), 1-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

Chemical Information

2-Hydroxyquinoline

Quinolin-2-ol is a monohydroxyquinoline carrying a hydroxy substituent at position 2. It is an intermediate metabolite produced duting the microbial degradation of quinoline. It has a role as a bacterial xenobiotic metabolite. It is a tautomer of a quinolin-2(1H)-one.

CAS Number59-31-4
PubChem CID6038
IUPAC Name1H-quinolin-2-one
Molecular FormulaC9H7NO
Molecular Weight145.16
XLogP1.3
Topological Polar Surface Area29.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count11
Formal Charge0
Complexity198
SMILES
C1=CC=C2C(=C1)C=CC(=O)N2
InChI
InChI=1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)
InChIKey
LISFMEBWQUVKPJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Hydroxyquinoline
CAS: 59-31-4
CID: 6038
Formula: C9H7NO
MW: 145.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight145.16
XLogP31.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass145.052763847
Monoisotopic Mass145.052763847
Topological Polar Surface Area29.1 Ų
Heavy Atom Count11
Formal Charge0
Complexity198
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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