8-Hydroxyquinoline

CAT: 0804-HY-B1005-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1005-01Size:100 mg
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Description
8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice[1][2][3][4][5].
CAS Number
[148-24-3]
Product Name Alternative
8-Quinolinol
UNSPSC
12352005
Hazard Statement
H301, H317, H318, H360, H410
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-Hydroxyquinoline.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=CC=C1
Molecular Formula
C9H7NO
Molecular Weight
145.16
Precautions
H301, H317, H318, H360, H410
References & Citations
[1]Lawung R, et.al. Repositioning of 8-hydroxyquinoline derivatives as a new promising candidate for combating multidrug resistant Neisseria gonorrhoeae. EXCLI J. 2018 Aug 23;17:840-846. |[2]8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells. J Biol Inorg Chem. 2010 Feb;15 (2) :259-69. |[3]Zhai S, et.al. Tumor cellular proteasome inhibition and growth suppression by |[4]Hamoud MA, et.al. Effects of quinoline and 8-hydroxyquinoline on mouse bone marrow erythrocytes as measured by the micronucleus assay. Teratog Carcinog Mutagen. 1989;9 (2) :111-8. |[5]Searle CE. The selective depigmenting action of 8-hydroxyquinoline on hair growth in the mouse. Br J Dermatol. 1972 May;86 (5) :472-80.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched

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