8-Hydroxyquinoline

• Description :

  8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice[1][2][3][4][5].

• Product Name Alternative :

  8-Quinolinol

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H317, H318, H360, H410

• Target :

  Antibiotic; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/8-Hydroxyquinoline.html

• Concentration :

  10mM

• Purity :

  99.99

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC1=C2N=CC=CC2=CC=C1

• Molecular Formula :

  C9H7NO

• Molecular Weight :

  145.16

• Precautions :

  H301, H317, H318, H360, H410

• References & Citations :

  [1]Lawung R, et.al. Repositioning of 8-hydroxyquinoline derivatives as a new promising candidate for combating multidrug resistant Neisseria gonorrhoeae. EXCLI J. 2018 Aug 23;17:840-846. |[2]8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells. J Biol Inorg Chem. 2010 Feb;15 (2) :259-69. |[3]Zhai S, et.al. Tumor cellular proteasome inhibition and growth suppression by |[4]Hamoud MA, et.al. Effects of quinoline and 8-hydroxyquinoline on mouse bone marrow erythrocytes as measured by the micronucleus assay. Teratog Carcinog Mutagen. 1989;9 (2) :111-8. |[5]Searle CE. The selective depigmenting action of 8-hydroxyquinoline on hair growth in the mouse. Br J Dermatol. 1972 May;86 (5) :472-80.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [148-24-3]