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SAP18 rabbit pAb

CAT: 0855-ES13202-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13202-01Size:50 µL
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Background
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Description
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008],
UniProt
O00422
Swiss Prot
O00422
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human SAP18
Target
SAP18
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Nucleus speckle . Shuttles between the nucleus and the cytoplasm (PubMed:16314458) . Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198) . .
Gene ID (Human)
10284

UniProtKB · O00422

Histone deacetylase complex subunit SAP18

SAP18_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00422
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SAP18
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R494, Q2TTR4, Q6IAW9, Q8N606, Q9UF14, X6RAL5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondUbl conjugation

Coding sequence diversity

Alternative initiation

Cellular component

CytoplasmNucleus

Biological process

mRNA processingmRNA splicingTranscriptionTranscription regulation

Molecular function

Repressor

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