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DC-LC3in-D5

CAT: 0804-HY-141882-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-141882-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy[1].
CAS Number
2868312-73-4
UNSPSC
12352005
Target
Atg8/LC3; Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dc-lc3in-d5.html
Purity
98.62
Solubility
DMSO : 35.71 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1/C(C(CC(C2=C(Cl)C(Cl)=CC=C2)C1)=O)=C/NCCN3CCOCC3
Molecular Formula
C19H22Cl2N2O3
Molecular Weight
397.30
References & Citations
[1]Shijie Fan, et al. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60 (50) :26105-26114.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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