TP-5801 (TFA)

• Description:

  TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity[1].

• UNSPSC:

  12352005

• Target:

  STAT; TNK1

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tp-5801-tfa.html

• Purity:

  99.55

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC(C(F)(F)F)=O.CN1CCN(C2=C(C)C=C(NC3=NC=C(Br)C(NC4=CC=CN=C4N(C)C)=N3)C(OC)=C2)CC1

• Molecular Formula:

  C26H32BrF3N8O3

• Molecular Weight:

  641.48

• References & Citations:

  [1]Tsz-Yin Chan, et al. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 Sep 9;12 (1) :5337.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported