CENP-M rabbit pAb

• Background:

  The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

• Description:

  The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],

• UniProt:

  Q9NSP4

• Swiss Prot:

  Q9NSP4

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human CENP-M AA range: 30-110

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IHC; IF; WB

• Concentration:

  1 mg/ml

• Dilution:

  IHC-p 1:50-200, WB 1:500-2000

• Molecular Weight:

  20kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  20kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity) . Localizes in the kinetochore domain of centromeres. .

• Other Product Names:

  Centromere protein M (CENP-M; Interphase centromere complex protein 39; Proliferation-associated nuclear element protein 1)

• Gene ID (Human):

  79019