CENP-A (phospho Ser7) rabbit pAb

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Background

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

Description

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015],

Product Name Alternative

CENPA; Histone H3-like centromeric protein A; Centromere autoantigen A; Centromere protein A; CENP-A

UniProt

P49450

Swiss Prot

P49450

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human Centromeric Protein A around the phosphorylation site of Ser7. AA range:1-50

Target

CENP-A

Clonality

Polyclonal

Source

Rabbit

Applications

IF; ELISA

Concentration

1 mg/ml

Dilution

Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Buffer

-20°C/1 year

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus . Chromosome, centromere, kinetochore . Chromosome, centromere . Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591) . Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658) . .

Other Product Names

CENPA; Histone H3-like centromeric protein A; Centromere autoantigen A; Centromere protein A; CENP-A

Gene ID (Human)

1058

UniProtKB · P49450

Histone H3-like centromeric protein A

CENPA_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P49450
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CENPA
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: D6W544, Q53T74, Q9BVW2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

ADP-ribosylationMethylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell divisionHost-virus interactionMitosis

Cellular component

CentromereChromosomeNucleosome coreNucleus

Molecular function

DNA-binding

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