M-RIP rabbit pAb

• Background:

  Function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells., similarity:Contains 1 PH domain., similarity:Contains 2 PH domains., subcellular location:Colocalizes with F-actin., subunit:Binds F-actin through its N-terminus (By similarity) . Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

• Description:

  Function: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. similarity: Contains 1 PH domain. similarity: Contains 2 PH domains. subcellular location: Colocalizes with F-actin. subunit: Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

• UniProt:

  Q6WCQ1

• Swiss Prot:

  Q6WCQ1

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from the Internal region of human M-RIP.

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA; IHC

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight:

  115kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  115kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm, cytoskeleton . Colocalizes with F-actin.

• Other Product Names:

  MPRIP; KIAA0864; MRIP; RHOIP3; Myosin phosphatase Rho-interacting protein; M-RIP; Rho-interacting protein 3; RIP3; p116Rip

• Gene ID (Human):

  23164/23164