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M-cadherin rabbit pAb

CAT: 0855-ES2759-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2759-01Size:50 µL
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Background
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
Description
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008],
UniProt
P55291
Swiss Prot
P55291
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CDH15. AA range:81-130
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
89kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
89kD
Fragment
IgG
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Other Product Names
CDH15; CDH14; CDH3; Cadherin-15; Cadherin-14; Muscle cadherin; M-cadherin
Gene ID (Human)
1013

UniProtKB · P55291

Cadherin-15

CAD15_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55291
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDH15
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

Coding sequence diversity

Chromosomal rearrangement

PTM

Cleavage on pair of basic residuesGlycoprotein

Disease

Disease variantIntellectual disability

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

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