LP-533401

• Description :

  LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Tryptophan Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/LP-533401.html

• Concentration :

  10mM

• Purity :

  99.02

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  N[C@@H](CC1=CC=C(C2=NC(N)=NC(OC(C3=CC=C(C4=CC=CC(F)=C4)C=C3)C(F)(F)F)=C2)C=C1)C(O)=O

• Molecular Formula :

  C27H22F4N4O3

• Molecular Weight :

  526.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16 (3), 308-312 (2010) .|[2]Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303 (6) :L500-8.|[3]Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124 (18) :2834-46.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  Cell Signal. 2023 May:105:110612.|iMetaOmics. 2024 Oct 14.|iScience. 2025 Nov 18.|Life Sci. 2021 Nov 15:285:120002.|Nat Aging. 2024 Feb 6.|Nat Aging. 2024 Mar;4 (3) :414-433.

• CAS Number :

  [945976-43-2]