LP-533401

CAT: 0804-HY-15849-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15849-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
CAS Number
[945976-43-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/LP-533401.html
Concentration
10mM
Purity
99.02
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N[C@@H](CC1=CC=C(C2=NC(N)=NC(OC(C3=CC=C(C4=CC=CC(F)=C4)C=C3)C(F)(F)F)=C2)C=C1)C(O)=O
Molecular Formula
C27H22F4N4O3
Molecular Weight
526.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16 (3), 308-312 (2010) .|[2]Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303 (6) :L500-8.|[3]Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124 (18) :2834-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Signal. 2023 May:105:110612.|iMetaOmics. 2024 Oct 14.|iScience. 2025 Nov 18.|Life Sci. 2021 Nov 15:285:120002.|Nat Aging. 2024 Feb 6.|Nat Aging. 2024 Mar;4 (3) :414-433.

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