pro Caspase 10 Recombinant Rabbit Monoclonal Antibody [JE59-42]

pro Caspase 10 Recombinant Rabbit Monoclonal Antibody [JE59-42]

• Description: Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. That protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Product Name Alternative: Apoptotic protease Mch4 antibody CASP10 antibody Caspase 10 antibody FLICE2 antibody ICE like apoptotic protease 4 antibody
• Abbreviation: CASP10, MCH4
• CAS Number: 9000-83-3
• Swiss Prot: Q92851 Human
• Cellular Locus: Cytoplasm, cytosol, ripoptosome.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human Caspase 10 aa 181-280 / 521.
• Isotype: IgG
• Clone: JE59-42
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HepG2 cell lysate, A431 cell lysate, K-562 cell lysate, human breast cancer tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 59 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes