Caspase-5 Recombinant Rabbit Monoclonal Antibody [SD203-2]

Caspase-5 Recombinant Rabbit Monoclonal Antibody [SD203-2]

• Description: Caspases are cysteine proteases which play important roles in the activation of cytokines and in apoptosis. The ICE subfamily of caspases comprises peptides closely related to caspase-1, which promotes maturation of interleukin 1β (IL-1β) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides. Both caspase-4 and caspase-5 are members of the caspase-1 subfamily, and are more closely related to each other than to other homologues. Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.
• Product Name Alternative: Caspase5 Apoptosis related cysteine protease antibody CASP-5 antibody CASP5 antibody CASP5_HUMAN antibody Caspase-5 subunit p10 antibody Caspase-5 antibody Caspase 5 antibody Caspase5 antibody ICE (rel)-III antibody ICERELIII antibody ICH 3 antibody ICH 3 protease antibody Protease ICH-3 antibody Protease TY antibody TY antibody TY protease antibody
• Abbreviation: CASP-5, CASP5
• CAS Number: 9000-83-3
• Swiss Prot: P51878 Human
• Cellular Locus: NLRP1 inflammasome complex, cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Caspase 5 aa 1-50 / 434.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP
• Positive Control: A549, Hela, SHG-44, human liver tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 50 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes