DMX-5804

• Description:

  DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96) . DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MAP4K

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/DMX-5804.html

• Purity:

  99.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1NC=NC2=C1C (C3=CC=C (OCCOC) C=C3) =CN2C4=CC=CC=C4

• Molecular Formula:

  C21H19N3O3

• Molecular Weight:

  361.39

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909 (19) 30013-X.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MAP4K2/GCK; MAP4K3/GLK; MAP4K4/HGK; MAP4K5/KHS1; MAP4K6/MINK1; MAP4K7/TNIK

• CAS Number:

  2306178-56-1