IKKβ-IN-3

• Description :

  IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC50 value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis[1].

• UNSPSC :

  12352005

• Target :

  IKK

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ikkβ-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C[C@H](NC(C[C@H](CC(CC1=CC=CC=C1)=O)O)=O)CO)C

• Molecular Formula :

  C18H27NO4

• Molecular Weight :

  321.41

• References & Citations :

  [1]Li L, et al. The discovery of a novel IκB kinase β inhibitor based on pharmacophore modeling, virtual screening and biological evaluation. Future Med Chem. 2024;16 (6) :531-544.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IKK-β