IKKβ-IN-4

• Description:

  IKKβ-IN-4 (compound 14) is an IkappaB kinase-β (IKKβ) inhibitor with IC50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  IKK

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ikkβ-in-4.html

• Purity:

  99.94

• Solubility:

  DMSO : 116.67 mg/mL (ultrasonic)

• Smiles:

  NC (SC (C1=CC=CC=C1) =C2) =C2C (N) =O

• Molecular Formula:

  C11H10N2OS

• Molecular Weight:

  218.27

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Morwick T, et al. Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49 (10) :2898-908. 16686533.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IKK-β

• CAS Number:

  4815-35-4