IKKβ-IN-4

CAT: 0804-HY-W028127-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W028127-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IKKβ-IN-4 (compound 14) is an IkappaB kinase-β (IKKβ) inhibitor with IC50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases[1].
CAS Number
[4815-35-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ikkβ-in-4.html
Purity
99.94
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
NC(SC(C1=CC=CC=C1)=C2)=C2C(N)=O
Molecular Formula
C11H10N2OS
Molecular Weight
218.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Morwick T, et al. Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49 (10) :2898-908. 16686533.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β

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