TBK1/IKKε-IN-5

• UNSPSC Description:

  TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC50 values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity[1].

• Target Antigen:

  IKK

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tbk1-ikk-epsilon-in-5.html

• Purity:

  99.23

• Solubility:

  DMSO : 7.81 mg/mL (ultrasonic)

• Smiles:

  N#CC1=CC(C2=NC(NC3=CC=C(N4CCN(C5COC5)CC4)C=C3)=NC=N2)=CC=C1OC6CCOCC6

• Molecular Weight:

  513.59

• References & Citations:

  [1]Jenkins RW, et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018 Feb;8(2):196-215.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1893397-65-3