IKK-IN-4

• Description:

  IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC50s of 45 and 650 nM for IKKβ and IKKα, respectively[1].

• UNSPSC:

  12352005

• Target:

  IKK

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ikk-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CN=C2C (NC) =NC (C=C (C3=CC=CC (CCN) =C3) S4) =C4N21

• Molecular Formula:

  C18H19N5S

• Molecular Weight:

  337.44

• References & Citations:

  [1]Belema M, et al. Synthesis and structure-activity relationship of imidazo (1,2-a) thieno (3,2-e) pyrazines as IKK-beta inhibitors. Bioorg Med Chem Lett. 2007;17 (15) :4284‐4289.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  615529-94-7