IKK 16

IKK 16

• CAS Number: 873225-46-8
• UNSPSC Description: IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.
• Target Antigen: IKK; LRRK2
• Type: Reference compound
• Related Pathways: Autophagy;NF-κB
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/IKK-16.html
• Smiles: O=C(C1=CC=C(NC2=NC=CC(C3=CC4=CC=CC=C4S3)=N2)C=C1)N5CCC(N6CCCC6)CC5
• Molecular Weight: 483.63
• References & Citations: [1]Waelchli R, et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12.|[2]Hermanson SB, et al. Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation. PLoS One. 2012;7(8):e43580.|[3]Coldewey SM, et al. Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Model Mech. 2013 Jul;6(4):1031-42.
• Shipping Conditions: Room Temperature