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DHFR-IN-17

CAT: 0804-HY-162358Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162358Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL[1].
UNSPSC
12352005
Target
Bacterial; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-17.html
Solubility
10 mM in DMSO
Smiles
CC(C1=C(C=C(C(OCC2CC2)=C1)I)OC3=CN=C(N=C3N)N)C
Molecular Formula
C17H21IN4O2
Molecular Weight
440.28
References & Citations
[1]Huang Z, et al. Design, Synthesis, and Biological Evaluation of 5- (5-Iodo-2-isopropyl-4-methoxyphenoxy) pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus. J Med Chem. Published online March 11, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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