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PLpro-IN-8

CAT: 0804-HY-168259Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168259Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLpro-IN-8 (compound 1) is a SARS-CoV papain-like protease (PLpro) inhibitor with IC50 values of 5.9 μM and 0.46 μM for SARS-CoV-2 PLpro and SARS -CoV-1 PLpro, respectively. PLpro-IN-8 inhibits Wuhan strain WK-521 of SARS-CoV-2 with an EC50 of 2.7 μM[1].
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/plpro-in-8.html
Smiles
C[C@@H](NC(C1=C(C)C=CC(CNC(C(O)=O)=O)=C1)=O)C2=CC=CC3=CC=CC=C32
Molecular Formula
C23H22N2O4
Molecular Weight
390.43
References & Citations
[1]Kouki Shinohara, et al. Naphthalen-1-ylethanamine-containing small molecule inhibitors of the papain-like protease of SARS-CoV-2. Eur J Med Chem. 2024 Oct 18:280:116963.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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