PLpro-IN-3

• UNSPSC Description:

  PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC50 of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC50 of 4.3 μM[1].

• Target Antigen:

  SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/plpro-in-3.html

• Smiles:

  O=C(C1=CC=C(CNC2=CC(C3=NOC(C(C4=CC=C(C5=CC=CC=C5)C(F)=C4)C)=N3)=CC=C2C)S1)O

• Molecular Weight:

  513.58

• References & Citations:

  [1]Qin B, et al. Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors. J Med Chem. 2024 Jun 27;67(12):10211-10232.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3047093-72-8