PLpro-IN-3

CAT: 0804-HY-161729Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161729Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC50 of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC50 of 4.3 μM[1].
CAS Number
[3047093-72-8]
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/plpro-in-3.html
Smiles
O=C(C1=CC=C(CNC2=CC(C3=NOC(C(C4=CC=C(C5=CC=CC=C5)C(F)=C4)C)=N3)=CC=C2C)S1)O
Molecular Formula
C29H24FN3O3S
Molecular Weight
513.58
References & Citations
[1]Qin B, et al. Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors. J Med Chem. 2024 Jun 27;67 (12) :10211-10232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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