PLpro-IN-3

• Description :

  PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC50 of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC50 of 4.3 μM[1].

• UNSPSC :

  12352005

• Target :

  SARS-CoV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/plpro-in-3.html

• Smiles :

  O=C(C1=CC=C(CNC2=CC(C3=NOC(C(C4=CC=C(C5=CC=CC=C5)C(F)=C4)C)=N3)=CC=C2C)S1)O

• Molecular Formula :

  C29H24FN3O3S

• Molecular Weight :

  513.58

• References & Citations :

  [1]Qin B, et al. Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors. J Med Chem. 2024 Jun 27;67 (12) :10211-10232.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3047093-72-8]