PLpro-IN-9

• Description :

  PLpro-IN-9 (Compound 14e) is a SARS-CoV-2 PLpro inhibitor with an IC50 of 12.0 μM and a KD of 1.86 μM. PLpro-IN-9 has low cytotoxicity but poor metabolic stability. PLpro-IN-9 can be used in the research of SARS-CoV-2[1].

• UNSPSC :

  12352100

• Target :

  SARS-CoV

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=C(NC1=CC(C2=CC(NS(=O)(C3=CC=CC=C3)=O)=CC=C2)=NN1)C(S4)=CC=C4C=O

• Molecular Formula :

  C21H16N4O4S2

• Molecular Weight :

  452.51

• References & Citations :

  [1]Wu C, et al. Discovery of 3-phenyl-1H-5-pyrazolylamides as PLpro inhibitors through virtual screening and structure optimization. Bioorg Med Chem Lett. 2025 Jun 3;127:130293.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported