PLpro-IN-9

• Description:

  PLpro-IN-9 (Compound 14e) is a SARS-CoV-2 PLpro inhibitor with an IC50 of 12.0 μM and a KD of 1.86 μM. PLpro-IN-9 has low cytotoxicity but poor metabolic stability. PLpro-IN-9 can be used in the research of SARS-CoV-2[1].

• UNSPSC:

  12352100

• Target:

  SARS-CoV

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C (NC1=CC (C2=CC (NS (=O) (C3=CC=CC=C3) =O) =CC=C2) =NN1) C (S4) =CC=C4C=O

• Molecular Formula:

  C21H16N4O4S2

• Molecular Weight:

  452.51

• References & Citations:

  [1]Wu C, et al. Discovery of 3-phenyl-1H-5-pyrazolylamides as PLpro inhibitors through virtual screening and structure optimization. Bioorg Med Chem Lett. 2025 Jun 3;127:130293.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported