Mpro/PLPro-IN-2

• Description:

  Mpro/PLPro-IN-2 (Compound 22l) is a non-covalent competitive dual inhibitor of the papain-like protease and main protease of SARS-CoV-2, with a Ki of 0.2 μM for the papain-like protease and a Ki of 1.1 μM for the main protease[1]. Mpro/PLPro-IN-2 can be used in the research field of anti-SARS-CoV-2[1].

• UNSPSC:

  12352005

• Target:

  SARS-CoV; Virus Protease

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C(NNC1=NC(C)=C(C(OCC)=O)S1)/C=C/C2=CC=CC=C2

• Molecular Formula:

  C16H17N3O3S

• Molecular Weight:

  331.39

• References & Citations:

  [1]Alli VJ, et al. Development of acylhydrazone linked thiazoles as non-covalent dual inhibitors of SARS-CoV-2 proteases. Eur J Med Chem. 2025 Jun 5;290:117509.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported