ACT-678689

• Description:

  ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

• UNSPSC:

  12352005

• Target:

  Tryptophan Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/act-678689.html

• Purity:

  99.91

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CS(=O)(NC1=NC(Cl)=C(OCC(N2CCC3=C(N4C(SC(C)=N4)=N3)[C@@H]2C5=CC=C(C)C=C5F)=O)C=C1)=O

• Molecular Formula:

  C23H22ClFN6O4S2

• Molecular Weight:

  565.04

• References & Citations:

  [1]Daniel Bur, et al. Tricyclic piperidine compounds. WO2015075023A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1783256-96-1