PF-06685249

• Product Name Alternative:

  HMR-1275; Alvocidib; L86-8275, Acetylisoniazide-d4; N-Monoacetylisoniazid-d4; NSC 36084-d14

• UNSPSC Description:

  PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research[1].

• Target Antigen:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PI3K/Akt/mTOR

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-06685249.html

• Purity:

  98.32

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CNC2=C1C=C(C3=CC=C(N(C)C)N=C3OC)C(Cl)=C2)O

• Molecular Weight:

  345.78

• References & Citations:

  [1]David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1467059-70-6