9-Methoxycamptothecin

• Description:

  9-Methoxycamptothecin (MCPT), isolated from Camptotheca acuminata, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Apoptosis; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/9-methoxycamptothecin.html

• Concentration:

  10mM

• Purity:

  99.13

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC[C@@]1 (C2=C (COC1=O) C (N3C (C4=NC5=CC=CC (OC) =C5C=C4C3) =C2) =O) O

• Molecular Formula:

  C21H18N2O5

• Molecular Weight:

  378.38

• Precautions:

  H301

• References & Citations:

  [1]Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66 (9-10) :471-6.|[2]Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  39026-92-1