9-Methoxycamptothecin

CAT: 0804-HY-N6011-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6011-01Size:5 mg
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Description
9-Methoxycamptothecin (MCPT), isolated from Camptotheca acuminata, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].
CAS Number
[39026-92-1]
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Topoisomerase
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/9-methoxycamptothecin.html
Concentration
10mM
Purity
99.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC[C@@]1(C2=C(COC1=O)C(N3C(C4=NC5=CC=CC(OC)=C5C=C4C3)=C2)=O)O
Molecular Formula
C21H18N2O5
Molecular Weight
378.38
Precautions
H301
References & Citations
[1]Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66 (9-10) :471-6.|[2]Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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