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10-Methoxycamptothecin

CAT: 0804-HY-N0446-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0446-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines[1].
CAS Number
19685-10-0
UNSPSC
12352005
Hazard Statement
H301
Target
ADC Payload
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/10-methoxycamptothecin.html
Purity
98.06
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(OC)=CC=C5N=C4C3=C2)=O
Molecular Formula
C21H18N2O5
Molecular Weight
378.38
Precautions
H301
References & Citations
[1]Zheng J, et al. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:81-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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