10-Methoxycamptothecin

• Description :

  10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines[1].

• CAS Number :

  [19685-10-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  ADC Payload

• Type :

  Natural Products

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/10-methoxycamptothecin.html

• Purity :

  98.06

• Solubility :

  DMSO : 8.33 mg/mL (ultrasonic)

• Smiles :

  O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(OC)=CC=C5N=C4C3=C2)=O

• Molecular Formula :

  C21H18N2O5

• Molecular Weight :

  378.38

• Precautions :

  H301

• References & Citations :

  [1]Zheng J, et al. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:81-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported