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ADP-β-S (trilithium)

CAT: 0804-HY-134353B-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134353B-01Size:1 mg
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Description
ADP-β-S trilithium is the trilithium salt form of ADP-β-S. ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome[1].
CAS Number
73536-95-5
Product Name Alternative
Adenosine 5'- (β-thiodiphosphate) (trilithium)
UNSPSC
12352005
Hazard Statement
H302, H371
Target
NF-κB; P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/adp-β-s-trilithium.html
Purity
94.9
Solubility
H2O : 20 mg/mL (ultrasonic; warming)
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N=CN=C32)N)O[C@@H]1COP(OP(O[Li])(S[Li])=O)(O[Li])=O
Molecular Formula
C10H12Li3N5O9P2S
Molecular Weight
461.07
Precautions
H302, H371
References & Citations
[1]Suzuki T, et al., Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. Eur J Immunol. 2020 Feb;50 (2) :205-219.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y12 Receptor

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