ADP-β-S (trilithium)

• UNSPSC Description:

  ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353). ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome[1].

• Target Antigen:

  NF-κB; P2Y Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;NF-κB

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/adp-β-s-trilithium.html

• Smiles:

  O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N=CN=C32)N)O[C@@H]1COP(OP(O[Li])(S[Li])=O)(O[Li])=O

• Molecular Weight:

  461.07

• References & Citations:

  [1]Suzuki T, et al., Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. Eur J Immunol. 2020 Feb;50(2):205-219.

• Shipping Conditions:

  Blue Ice

• CAS Number:

  73536-95-5