(S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2

(S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2

• UNSPSC Description: (S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the coupling conjugate of the E3 ubiquitin ligase ligand and linker for NX-2127 (HY-153220)[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/s-thalidomide-pyrrolidine-c-piperidine-ph-nh2.html
• Smiles: O=C1C2=CC(N3C[C@H](CN4CCC(C5=CC=C(N)C=C5)CC4)CC3)=CC=C2C(N1C6C(NC(CC6)=O)=O)=O
• Molecular Weight: 515.60
• References & Citations: [1]Robbins D W, et al. Discovery and preclinical pharmacology of NX-2127, an orally bioavailable degrader of Bruton’s tyrosine kinase with immunomodulatory activity for the treatment of patients with B cell malignancies[J]. Journal of Medicinal Chemistry, 2024, 67(4): 2321-2336.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported