Thalidomide-NHCH2-Ph-pyrimidine-NH2

Thalidomide-NHCH2-Ph-pyrimidine-NH2

• UNSPSC Description: Thalidomide-NHCH2-Ph-pyrimidine-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and a Linker Boc-NHCH2-Ph-pyrimidine-NH2 (HY-161499). Thalidomide-NHCH2-Ph-pyrimidine-NH2 is utilized for synthesis of PROTAC molecule XYD198 (HY-161498)[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-nhch2-ph-pyrimidine-nh2.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=CN=C(N=C1)C2=CC=C(C=C2)CNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O
• Molecular Weight: 456.45
• References & Citations: [1]Hu J, et al., Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity. J Med Chem. 2024 May 9;67(9):6952-6986.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported