Thalidomide-NHCH2-Ph-pyrimidine-NH2

• UNSPSC Description:

  Thalidomide-NHCH2-Ph-pyrimidine-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and a Linker Boc-NHCH2-Ph-pyrimidine-NH2 (HY-161499). Thalidomide-NHCH2-Ph-pyrimidine-NH2 is utilized for synthesis of PROTAC molecule XYD198 (HY-161498)[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-nhch2-ph-pyrimidine-nh2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=CN=C(N=C1)C2=CC=C(C=C2)CNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O

• Molecular Weight:

  456.45

• References & Citations:

  [1]Hu J, et al., Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity. J Med Chem. 2024 May 9;67(9):6952-6986.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported