Thalidomide-piperidine-O-Ph-NH2

Thalidomide-piperidine-O-Ph-NH2

• UNSPSC Description: Thalidomide-piperidine-O-Ph-NH2 is the conjugate of E3 ligase and linker. Thalidomide-piperidine-O-Ph-NH2 can be used for synthesis of PROTAC degrader MJP6412 (HY-168201)[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-piperidine-o-ph-nh2.html
• Smiles: O=C(NC1=O)CCC1N(C2=O)C(C3=C2C=C(C=C3)N4CCC(OC5=CC=C(N)C=C5)CC4)=O
• Molecular Weight: 448.47
• References & Citations: [1]Ma M, et al., Discovery of a Highly Potent PROTAC Degrader of p300/CBP Proteins for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2024 Sep 29.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported