(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
CAT:
804-HY-168304
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
- UNSPSC Description: (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127 (HY-153220A), which can be used in cancer research[1].
- Target Antigen: E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/thalidomide-pyrrolidine-c-piperidine-ph-nh2.html
- Smiles: O=C1C2=CC(N3C[C@@H](CN4CCC(C5=CC=C(N)C=C5)CC4)CC3)=CC=C2C(N1C6C(NC(CC6)=O)=O)=O
- Molecular Weight: 515.60
- References & Citations: [1]Daniel W Robbins, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67(4):2321-2336.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported