Schisandrol B

CAT: 0804-HY-N0692-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0692-01Size:5 mg
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Description
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities[1][2][3].
CAS Number
[58546-54-6]
Product Name Alternative
Gomisin-A; TJN-101; Wuweizi alcohol-B
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; Cytochrome P450; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Schisandrol-B.html
Purity
99.99
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@@]([C@@H](C)C1)(C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC
Molecular Formula
C23H28O7
Molecular Weight
416.46
Precautions
H302
References & Citations
[1]Jiang Y, et al. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015 Jan;143 (1) :107-15.|[2]Jin J, et al. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats. Biopharm Drug Dispos. 2010 May;31 (4) :264-8.|[3]Jeong-Seok Kim, et al. Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells. Clin Exp Pharmacol Physiol. 2018 Jun;45 (6) :547-555.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP2; CYP3

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