FAAH-IN-2

• Description:

  FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is an inhibitor of FAAH. FAAH-IN-2 is a metabolite of Gefitinib (HY-50895) [1][2][3].

• Product Name Alternative:

  O-Desmorpholinopropyl Gefitinib

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; FAAH

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/FAAH-IN-2.html

• Purity:

  99.29

• Solubility:

  DMSO : 20.83 mg/mL (ultrasonic)

• Smiles:

  OC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC

• Molecular Formula:

  C15H11ClFN3O2

• Molecular Weight:

  319.72

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Olivier Dasse, et al. Carbamates therapeutic release agents as amidase inhibitors. WO/2008/100977A2.|[2]Zhu Y, et al. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell Death Differ. 2023 Jan;30 (1) :168-183.|[3]Kumawat S, et al. Dearomative Difluoromethylation of N-Heterocycles and Pharmaceuticals with Bromo (difluoro) acetic Acid. J Org Chem. 2025 Jul 18;90 (28) :9826-9844.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  184475-71-6