Biotin Conjugated Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector)

Biotin Conjugated Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector)

• Description: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
• Product Name Alternative: Catabolin antibody H1 antibody IFN beta inducing factor antibody IL 1 antibody IL 1 beta antibody IL-1 beta antibody IL1 antibody IL1 BETA antibody IL1B antibody IL1B_HUMAN antibody IL1F2 antibody Interleukin 1 beta antibody Interleukin 1 beta precursor antibody interleukin 1, beta antibody Interleukin-1 beta antibody OAF antibody Osteoclast activating factor antibody OTTHUMP00000162031 antibody Preinterleukin 1 beta antibody Preinterleukin beta antibody Pro interleukin 1 beta antibody
• Abbreviation: Interleukin-1 beta IL-1 beta Il1b
• CAS Number: 9000-83-3
• Swiss Prot: Q63264 Rat
• Cellular Locus: Cytoplasm, Lysosome, Secreted.
• Host: Rabbit
• Species Reactivity: Rat
• Immunogen: Recombinant full length protein rat IL-1 beta.
• Isotype: IgG
• Clone: PS01-87
• Conjugation: Biotin-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): 1:1,000-1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes