Biotin Conjugated Human IL-4 Recombinant Rabbit Monoclonal Antibody [PS00-66] - BSA and Azide free (Detector)

Biotin Conjugated Human IL-4 Recombinant Rabbit Monoclonal Antibody [PS00-66] - BSA and Azide free (Detector)

• Description: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning. Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.
• Product Name Alternative: B cell growth factor 1 antibody B cell IgG differentiation factor antibody B Cell Stimulatory Factor 1 antibody B-cell stimulatory factor 1 antibody BCGF 1 antibody BCGF1 antibody Binetrakin antibody BSF-1 antibody BSF1 antibody IGG1 induction factor antibody IL 4 antibody IL-4 antibody IL4 antibody IL4_HUMAN antibody Il4e12 antibody Interleukin 4 antibody Interleukin 4 variant 2 antibody Interleukin 4, isoform 1 antibody Interleukin-4 antibody Lymphocyte stimulatory factor 1 antibody MGC79402 antibody Pitrakinra antibody
• Abbreviation: Interleukin-4 IL4 IL-4 B-cell stimulatory factor 1 (BSF-1) Binetrakin Lymphocyte stimulatory factor 1 Pitrakinra
• CAS Number: 9000-83-3
• Swiss Prot: P05112 Human
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant full length protein.
• Isotype: IgG
• Clone: PS00-66
• Conjugation: Biotin-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PS00-67] to IL-4 (Capture) (HA721230).
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Molecular Weight: Predicted band size: 17.5 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes