Biotin Conjugated Mouse IL-33 Recombinant Rabbit Monoclonal Antibody [PSH08-42] - Detector

Biotin Conjugated Mouse IL-33 Recombinant Rabbit Monoclonal Antibody [PSH08-42] - Detector

• Description: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets.
• Product Name Alternative: C9orf26 CHROMOSOME 9 OPEN READING FRAME 26 DKFZp586H0523 DVS27 DVS27 related protein IL 1F11 IL 33 IL-1F11 IL-33 IL1F11 IL33 IL33_HUMAN Interleukin 1 family member 11 Interleukin 33 INTERLEUKIN 33 NFHEV Interleukin 33 precursor Interleukin-1 family member 11 Interleukin-33 (109-270) Interleukin33 NF HEV NF-HEV NFEHEV NFHEV Nuclear factor for high endothelial venules Nuclear factor from high endothelial venules OTTHUMP00000021041 RP11 575C20.2
• Abbreviation: Interleukin-33 IL-33 Il33
• CAS Number: 9000-83-3
• Swiss Prot: Q8BVZ5 Mouse
• Cellular Locus: Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted.
• Host: Rabbit
• Species Reactivity: Mouse
• Immunogen: Recombinant protein within Mouse IL-33 aa 109-266 (HA210768).
• Isotype: IgG
• Clone: PSH08-42
• Conjugation: Biotin-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det), ELISA
• Positive Control: Recombinant Mouse IL-33 protein (HA210768).
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH08-41] to Mouse IL-33 antibody (Capture) (HA722985) and recombinant Mouse IL-33 protein (HA210768) as the standard. The reference range value is 15.6-2,000 pg/ml. ;ELISA: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes