Biotin Conjugated Mouse IL-10 Recombinant Rabbit Monoclonal Antibody [PS01-93]

Biotin Conjugated Mouse IL-10 Recombinant Rabbit Monoclonal Antibody [PS01-93]

• Description: IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. Over time a more nuanced picture of IL-10's function has emerged as treatment of tumor bearing mice has been shown to inhibit tumor metastasis. Additional investigation by multiple laboratories has generated data that further supports IL-10's immunostimulatory capacity in an immunoncology context. Expression of IL-10 from transfected tumor cell lines in IL-10 transgenic mice[30] or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. More recently, PEGylated recombinant murine IL-10 (PEG-rMuIL-10) has been shown to induce IFNγ and CD8+ T cell dependent anti-tumor immunity. More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells have at the site of an allergic reaction.
• Product Name Alternative: CSIF antibody Cytokine synthesis inhibitory factor antibody GVHDS antibody IL 10 antibody IL-10 antibody IL10 antibody IL10_HUMAN antibody IL10A antibody Interleukin 10 antibody Interleukin-10 antibody MGC126450 antibody MGC126451 antibody T-cell growth inhibitory factor antibody TGIF antibody
• Abbreviation: Il10, Il-10
• CAS Number: 9000-83-3
• Swiss Prot: P18893 Mouse
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Mouse
• Immunogen: Recombinant full length mouse il-10 protein.
• Isotype: IgG
• Clone: PS01-93
• Conjugation: Biotin-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PS01-85] to Mouse IL-10 (Capture) (HA721517). The reference range value is 13.72-10,000 pg/ml.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes