Biotin Conjugated Rat IL-2 Recombinant Rabbit Monoclonal Antibody [PS01-89] - BSA and Azide free (Detector)

Biotin Conjugated Rat IL-2 Recombinant Rabbit Monoclonal Antibody [PS01-89] - BSA and Azide free (Detector)

• Description: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
• Product Name Alternative: Aldesleukin antibody IL 2 antibody IL-2 antibody IL2 antibody IL2_HUMAN antibody Interleukin 2 antibody Interleukin-2 antibody interleukin2 antibody Involved in regulation of T cell clonal expansion antibody Lymphokine antibody OTTHUMP00000164090 antibody POIL2 antibody T Cell Growth Factor antibody T-cell growth factor antibody TCGF antibody
• Abbreviation: Interleukin-2 IL-2 T-cell growth factor (TCGF) Il2 Il-2
• CAS Number: 9000-83-3
• Swiss Prot: P17108 Rat
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Rat
• Immunogen: Recombinant full length protein rat IL-2.
• Isotype: IgG
• Clone: PS01-89
• Conjugation: Biotin-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): 1:1,000-1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes