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SKLB-D18

CAT: 1568-C03623-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C03623-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
ERK
Applications
MAPK
Additionnal Information
SKLB-D18 is a first-in-class, potent, and selective inhibitor of ERK1/2 and ERK5 with an IC50's of 38.69 nM, 40.12 nM, and 59.72 nM, respectively, that also acts as an agonist of autophagy. It modulates mTOR/p70S6K and NCOA4-mediated ferroptosis, showing strong anti-tumor activity and offering a promising monotherapy strategy to overcome resistance in ERK1/2-targeted therapy for triple-negative breast cancer (TNBC) .

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