4A7C-301

• UNSPSC Description:

  4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease[1].

• Target Antigen:

  Nuclear Hormone Receptor 4A/NR4A

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/4a7c-301.html

• Solubility:

  DMSO : 20 mg/mL (ultrasonic;warming)

• Smiles:

  ClC1=CC=C2C(NCCNC3=NC(N4CCN(CC)CC4)=CC(N5CCN(CC)CC5)=N3)=CC=NC2=C1

• Molecular Weight:

  524.10

• References & Citations:

  [1]Kim W, et al. An optimized Nurr1 agonist provides disease-modifying effects in Parkinson's disease models. Nat Commun. 2023 Jul 18;14(1):4283.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported