NFF-3 (TFA)

• Description :

  NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity[1].

• UNSPSC :

  12352209

• Target :

  MMP

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/nff-3-tfa.html

• Purity :

  98.54

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; adjust pH to 2 with HCl)

• Smiles :

  O=[N+]([O-])C(C=C(C=C1)[N+]([O-])=O)=C1NCCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C([C@H](CCCCN)NC([C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC(CC(C4=CC=C(OC)C=C4O5)=CC5=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O.OC(C(F)(F)F)=O

• Molecular Formula :

  C80H111F3N22O22

• Molecular Weight :

  1789.87

• References & Citations :

  [1]Giricz O, et al. Comparison of metalloproteinase protein and activity profiling. Anal Biochem. 2011 Feb 1;409 (1) :37-45.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-10; MMP-3