RFRP-3 (human) (TFA)

• Description :

  RFRP-3 (Neuropeptide VF (124-131) ) (human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3 (human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].

• Product Name Alternative :

  Neuropeptide VF (124-131) (human) (TFA) ; Neuropeptide NPVF (human) (TFA)

• UNSPSC :

  12352209

• Target :

  Neuropeptide Y Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/rfrp-3-human-tfa.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H]2N(C([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H]3N(C([C@H](C(C)C)N)=O)CCC3)=O)=O)=O)CCC2)=O)=O)=O.OC(C(F)(F)F)=O

• Molecular Formula :

  C47H73F3N14O12

• Molecular Weight :

  1083.16

• References & Citations :

  [1] Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported