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RFRP-3 (human) (TFA)

CAT: 0804-HY-P1250ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P1250ASize:1 Each
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Description
RFRP-3 (Neuropeptide VF (124-131) ) (human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3 (human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].
Product Name Alternative
Neuropeptide VF (124-131) (human) (TFA) ; Neuropeptide NPVF (human) (TFA)
UNSPSC
12352209
Target
Neuropeptide Y Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rfrp-3-human-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H]2N(C([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H]3N(C([C@H](C(C)C)N)=O)CCC3)=O)=O)=O)CCC2)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C47H73F3N14O12
Molecular Weight
1083.16
References & Citations
[1] Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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