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Meloxicam-13C, d3

CAT: 0804-HY-B0261S2Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0261S2Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Meloxicam-13C, d3 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.
CAS Number
1309936-00-2
UNSPSC
12352005
Target
Apoptosis; Autophagy; COX; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Purity
99.90
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=CC=C12)=C(C(NC3=NC=C(S3)C)=O)N([13C]([2H])([2H])[2H])S2(=O)=O
Molecular Formula
C13 13CH10D3N3O4S2
Molecular Weight
355.41
References & Citations
[2]Fikry EM, et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32 (2) .|[3]Iturriaga MP, et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14 (2) :2198-2206.|[4]Lazer ES, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997 Mar 14;40 (6) :980-9.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

Meloxicam-13CD3
CAS Number1309936-00-2
PubChem CID76973250
IUPAC Name4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2-(trideuterio(113C)methyl)-1lambda6,2-benzothiazine-3-carboxamide
Molecular FormulaC14H13N3O4S2
Molecular Weight355.4
XLogP3
Topological Polar Surface Area136
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity628
SMILES
[2H][13C]([2H])([2H])N1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=NC=C(S3)C
InChI
InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)/i2+1D3
InChIKey
ZRVUJXDFFKFLMG-JVXUGDAPSA-N
Chemical Structure
2D Structure
2D structure of Meloxicam-13CD3
CAS: 1309936-00-2
CID: 76973250
Formula: C14H13N3O4S2
MW: 355.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight355.4
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass355.05693332
Monoisotopic Mass355.05693332
Topological Polar Surface Area136 Ų
Heavy Atom Count23
Formal Charge0
Complexity628
Isotope Atom Count4
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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