Meloxicam-d3-1

• Description :

  Meloxicam-d3-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy; COX

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy; Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology; Cancer

• Purity :

  98.0

• Solubility :

  10 mM in DMSO|DMSO : 25mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 0.67mg/mL (ultrasonic)

• Smiles :

  OC(C1=CC=CC=C12)=C(C(NC3=NC=C(S3)C([2H])([2H])[2H])=O)N(C)S2(=O)=O

• Molecular Formula :

  C14H10D3N3O4S2

• Molecular Weight :

  354.42

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Lazer ES, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997 Mar 14;40 (6) :980-9.|[3]Iturriaga MP, et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14 (2) :2198-2206.|[4]Fikry EM, et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32 (2) .

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1227358-55-5]