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Meloxicam-d3-1

CAT: 0804-HY-B0261S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0261S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Meloxicam-d3-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.
CAS Number
[1227358-55-5]
UNSPSC
12352005
Target
Apoptosis; Autophagy; COX
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation
Field of Research
Inflammation/Immunology; Cancer
Purity
98.0
Solubility
10 mM in DMSO|DMSO : 25mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 0.67mg/mL (ultrasonic)
Smiles
OC(C1=CC=CC=C12)=C(C(NC3=NC=C(S3)C([2H])([2H])[2H])=O)N(C)S2(=O)=O
Molecular Formula
C14H10D3N3O4S2
Molecular Weight
354.42
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Lazer ES, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997 Mar 14;40 (6) :980-9.|[3]Iturriaga MP, et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14 (2) :2198-2206.|[4]Fikry EM, et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32 (2) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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