Eplerenone-13C, d3

CAT: 0804-HY-B0251S1Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B0251S1Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Eplerenone-13C, d3 (Epoxymexrenone-13C, d3) is 13C labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB) . Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) [1][2].
Product Name Alternative
Epoxymexrenone-13C, d3
UNSPSC
12352211
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Mineralocorticoid Receptor
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Smiles
C[C@@]12[C@]34[C@]([C@@H](CC1=CC(CC2)=O)C(O[13C]([2H])([2H])[2H])=O)([H])[C@@]5([H])[C@](C[C@@]3([H])O4)([C@]6(CCC(O6)=O)CC5)C
Molecular Formula
C23 13CH27D3O6
Molecular Weight
418.50
References & Citations
[3]Shlomo Keidar, et al. Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 2003 Jun;41 (6) :955-63. |[4]Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73 (13) : p. 1451-62.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Myron H Weinberger, et al. Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am J Hypertens. 2002 Aug;15 (8) :709-16.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B0251SEplerenone-d3
HY-111772SElexacaftor-13C, d3
HY-143848STadalafil-13C, d3
HY-B0002BS2Ondansetron-13C, d3
HY-B0220S1Erythromycin-13C, d3
HY-100427SImazamox-13C, d3
HY-50904S1Nintedanib-13C, d3
HY-10241S-01Simeprevir-13C, d3
HY-10219S1-01Rapamycin-13C, d3
HY-15408STrelagliptin-13C, d3

Alternative Products

CatalogName
sc-203943Eplerenone
RM-E181400-01(+) -Eplerenone
TRC-E588770-2.5MG7Beta-Eplerenone
sc-4960277β-Eplerenone
sc-218322Eplerenone-d3
448338-01Eplerenone discontinued
RM-E181407-01Eplerenone EP Impurity C; δ9,11-Eplerenone

Popular Products